The Role of Vitamins and Minerals in Hair Loss a Review Dermatological Therapies

You may recognize vitamin B7 by its popular name of biotin. It is a water-soluble B vitamin institute naturally in some foods and as well in supplements. Biotin plays a vital role in assisting enzymes to pause downwardly fats, carbohydrates, and proteins in food. It also helps to regulate signals sent by cells and the activity of genes. [1]

Recommended Amounts

An RDA (Recommended Dietary Allowance) does not exist for biotin because there is non plenty evidence to advise a daily amount needed past near healthy people. Instead, there is an AI (Acceptable Intake) level, which is causeless to ensure nutritional capability.

AI: The AI for biotin for men and women xix years and older and for pregnant women is 30 micrograms daily. Lactating women demand 35 micrograms daily.

UL: A Tolerable Upper Intake Level (UL) is the maximum daily dose unlikely to cause adverse side effects in the general population. There is no UL for biotin due to a lack of reports showing negative effects from very high intakes.

Vitamin B7 and Wellness

Biotin supplements are oft glamorized as a treatment for pilus loss and to promote healthy pilus, skin, and nails. Although a deficiency of biotin can certainly lead to hair loss and pare or smash bug, show showing a benefit of supplementation is inconclusive. A handful of case reports and small trials have shown a benefit, just the written report designs had weaknesses:

• The diagnoses of the type of hair conditions varied or were not cited at all. Researchers accept also noted that sure hair loss conditions like alopecia can resolve spontaneously without handling, and so it is not clear that biotin supplements specifically caused the regrowth. [2]
• The studies did not measure the participants' baseline blood levels of biotin to see if they were normal or deficient. Some enquiry suggests that biotin supplements may be of most benefit in people who have a deficiency of the nutrient; however, once again, there is a lack of studies that have measured biotin levels before and during supplementation to confirm this conclusion. [3,4]
• To appointment, there is a lack of published studies to suggest that biotin supplements are beneficial for the growth of normal, good for you pilus and nails. [2,5]

Despite the inconclusive testify, biotin supplements remain popular. Between 1999 and 2016, the proportion of supplement users increased by most thirtyfold. [half-dozen] In November 2017, the U.S. Food and Drug Administration (FDA) issued a warning based on reports of biotin supplements interfering with laboratory blood tests, causing incorrect results. High doses have produced either falsely elevated or decreased blood levels, depending on the test. This has affected lab results of certain hormones, such as thyroid-stimulating hormone and vitamin D, as well every bit a biomarker for heart attacks called troponin. [7] Case reports of this occurrence showed people taking biotin amounts much higher than the AI level (xxx micrograms daily or 0.03 mg) only in doses commonly found in supplements (10-300 mg). Biotin is frequently added to multivitamins and hair/nail/pare supplements. The FDA recommends that people inform their doctors at each visit of all supplements and doses they are taking.

Food Sources

• Beefiness liver
• Eggs (cooked)
• Salmon
• Avocados
• Pork
• Sweet potato
• Nuts, seeds

Signs of Deficiency and Toxicity

Deficiency

A biotin deficiency in the U.S. is rare, as near people swallow plenty biotin in a varied nutrition. Alcoholism tin increase the gamble of biotin deficiency and many other nutrients as alcohol tin can cake their absorption, and also considering alcohol abuse is generally associated with a poor dietary intake. About a tertiary of pregnant women testify a balmy biotin deficiency despite eating adequate intakes, though the exact reason is non clear. [1]

Symptoms appearing with a biotin deficiency:

• Thinning hair
• Scaly skin rashes around optics, nose, rima oris
• Brittle nails

Toxicity

No bear witness in humans has shown a toxicity of biotin even with high intakes. Because information technology is water-soluble, whatever excess amount will get out through the urine. There is no established upper limit or toxic level for biotin.

Did Yous Know?

Those who oftentimes enjoy raw eggs in recipes for mayonnaise, Caesar dressing, or eggnog may want to reconsider. A protein in raw eggs called avidin can bind to biotin, preventing its absorption. Cooked eggs are not an issue because avidin is broken down when heated.

Related

B Vitamins
Vitamins and Minerals

References

1. National Institutes of Health; Function of Dietary Supplements. Biotin: Fact Sheet for Health Professionals. https://ods.od.nih.gov/factsheets/Biotin-HealthProfessional/. Accessed vi/10/19.
2. Walth CB, Wessman LL, Wipf A, Carina A, Hordinsky MK, Farah RS. Response to: "Rethinking biotin therapy for hair, smash, and skin disorders". Journal of the American University of Dermatology. 2018 Dec 1;79(half dozen):e121-4.
3. Lipner SR. Rethinking biotin therapy for hair, nail, and skin disorders. Journal of the American University of Dermatology. 2018 Jun i;78(6):1236-8.
4. Lipner Due south. Reply to:"Response to 'Rethinking biotin therapy for hair, smash, and skin disorders'". Periodical of the American Academy of Dermatology. 2018 December ane;79(six).
5. Patel DP, Swink SM, Castelo-Soccio L. A review of the apply of biotin for hair loss. Pare appendage disorders. 2017;iii(three):166-9.
6. Li D, Rooney MR, Burmeister LA, Basta NE, Lutsey PL. Trends in Daily Use of Biotin Supplements Among Us Adults, 1999-2016. JAMA. 2020 Aug 11;324(vi):605-7.
7. Southward. Nutrient and Drug Assistants. The FDA Warns that Biotin May Interfere with Lab Tests: FDA Safety Communication. https://world wide web.fda.gov/medical-devices/rubber-communications/fda-warns-biotin-may-interfere-lab-tests-fda-safety-communication Accessed June 10, 2019.

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Source: https://www.hsph.harvard.edu/nutritionsource/biotin-vitamin-b7/

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